LIF recombinant protein

Recombinant Human LIF Protein (Fc Tag)

Cat. Num. AAA2552285

• Gene Names: LIF; CDF; DIA; HILDA; MLPLI
• Purity: >95% as determined by SDS-PAGE.
• Synonyms: LIF; Recombinant Human LIF Protein (Fc Tag); CDF; DIA; HILDA; Leukemia Inhibitory Factor; MLPLI; LIF recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE.
• Sequence Positions: Met1-Phe202
• Sequence Length: 88

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by the LAL method
• Fusion Tag: Fc Tag
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C. Store it under sterile conditions at -20 degree C to -80 degree C.; It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Related Product Information for LIF recombinant protein

Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It’s involved in growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. LIF has potent proinflammatory property, being the inducer of the acute phase protein synthesis and affecting the cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic and neuronal cells. LIF binds to the specific LIF receptor (LIFR-α) which forms a heterodimer with a specific subunit common to all members of that family of receptors, the GP130 signal transducing subunit. This leads to activation of the JAK/STAT and MAPK cascades. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origin.

NCBI and Uniprot Product Information

• NCBI GI #: 380418324
• NCBI GeneID: 3976
• NCBI Accession #: NP_001244064.1
• NCBI GenBank Nucleotide #: NM_001257135.1
• UniProt Accession #: P15018; Q52LZ2; B2RCW7; B5MC23
• Molecular Weight: Molecular Mass: 46.7 kDa; Actual Protein Molecular Mass: 63 kDa
• NCBI Official Full Name: leukemia inhibitory factor isoform 2
• NCBI Official Synonym Full Names: LIF, interleukin 6 family cytokine
• NCBI Official Symbol: LIF
• NCBI Official Synonym Symbols: CDF; DIA; HILDA; MLPLI
• NCBI Protein Information: leukemia inhibitory factor
• UniProt Protein Name: Leukemia inhibitory factor
• Protein Family: Leukemia inhibitory factor
• UniProt Gene Name: LIF
• UniProt Synonym Gene Names: HILDA; LIF; D factor; MLPLI

NCBI Description

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Uniprot Description

LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.