Rabbit anti-Human NUP98 Polyclonal Antibody | anti-NUP98 antibody

NUP98 Antibody

Cat. Num. AAA9403082

• Gene Names: NUP98; ADIR2; NUP96; NUP196
• Reactivity: Human
• Applications: Western Blot
• Purity: Antigen affinity purification.
• Synonyms: NUP98; Polyclonal Antibody; NUP98 Antibody; ADIR2; NUP96; NUP196; anti-NUP98 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total NUP98 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 2.2 mg/ml (varies by lot)
• Sequence Length: 937

• Applicable Applications for anti-NUP98 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:200-1:1000
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide of human nucleoporin 98kDa
• Target Name: NUP98
• Preparation and Storage: Store at -20 degree C

Testing Data

(Gel: 6%SDS-PAGE Lysates (from left to right): Hela and K562 cellAmount of lysate: 40ug per lane Primary antibody: 1/350 dilution Secondary antibody dilution: 1/8000Exposure time: 1 minute)

Related Product Information for anti-NUP98 antibody

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC.

Product Categories/Family for anti-NUP98 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 56549643
• NCBI GeneID: 4928
• NCBI Accession #: NP_005378.4
• NCBI GenBank Nucleotide #: NM_005387.5
• UniProt Accession #: P52948; Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5
• Molecular Weight: 186,268 Da
• NCBI Official Full Name: nuclear pore complex protein Nup98-Nup96 isoform 3
• NCBI Official Synonym Full Names: nucleoporin 98kDa
• NCBI Official Symbol: NUP98
• NCBI Official Synonym Symbols: ADIR2; NUP96; NUP196
• NCBI Protein Information: nuclear pore complex protein Nup98-Nup96
• UniProt Protein Name: Nuclear pore complex protein Nup98-Nup96
• UniProt Gene Name: NUP98
• UniProt Synonym Gene Names: ADAR2; Nup98; Nup96
• UniProt Entry Name: NUP98_HUMAN

NCBI Description

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]

Uniprot Description

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Nup98 and Nup96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC.