Kremen protein 1 (Kremen1) Recombinant Protein | Kremen1 recombinant protein
Recombinant Rat Kremen protein 1 (Kremen1), partial
Gene Names
Kremen1; Kremen
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Kremen protein 1 (Kremen1); Recombinant Rat Kremen protein 1 (Kremen1); partial; Kremen1 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
21-392
Sequence
RPAPGPRPSP ECFTANGADY RGTQSWTALQ GGKPCLFWNE TFQHPYNTLK YPNGEGGLGE HNYCRNPDGD VSPWCYVAEH EDGVYWKYCE IPACQMPGNL GCYKDHGNPP PLTGTSKTSN KLTIQTCISF CRSQRFKFAG MESGYACFCG NNPDYWKHGE AASTECNNVC FGDHTQPCGG DGRIILFDTL VGACGGNYSS MAAVVYSPDF PDTYATGRVC YWTIRVPGAS RIHFNFTIFD IRDSADMVEL LDGYTHRVLV RFDGRSRPPL SFNVSLDFVI LYFFSDRINQ AQGFAVLYQA TKEEPPQERP AINQTLAEVI TEQANLSVSA AHSSKVLYVI TSSPSHPPQT VPGSHSWVPS VGASGHRVEG WT
Sequence Length
372
Species
Rat
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Kremen1 recombinant protein
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)
beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
51,869 Da
NCBI Official Full Name
kremen protein 1
NCBI Official Synonym Full Names
kringle containing transmembrane protein 1
NCBI Official Symbol
Kremen1
NCBI Official Synonym Symbols
Kremen
NCBI Protein Information
kremen protein 1
UniProt Protein Name
Kremen protein 1
Protein Family
UniProt Gene Name
Kremen1
UniProt Synonym Gene Names
Kremen
NCBI Description
a novel type-I transmembrane protein; may be involved in regulation of cellular responses in neuronal and/or muscle cells [RGD, Feb 2006]
Uniprot Description
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.
Similar Products
Product Notes
The Kremen1 kremen1 (Catalog #AAA1304230) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 21-392. The amino acid sequence is listed below: RPAPGPRPSP ECFTANGADY RGTQSWTALQ GGKPCLFWNE TFQHPYNTLK YPNGEGGLGE HNYCRNPDGD VSPWCYVAEH EDGVYWKYCE IPACQMPGNL GCYKDHGNPP PLTGTSKTSN KLTIQTCISF CRSQRFKFAG MESGYACFCG NNPDYWKHGE AASTECNNVC FGDHTQPCGG DGRIILFDTL VGACGGNYSS MAAVVYSPDF PDTYATGRVC YWTIRVPGAS RIHFNFTIFD IRDSADMVEL LDGYTHRVLV RFDGRSRPPL SFNVSLDFVI LYFFSDRINQ AQGFAVLYQA TKEEPPQERP AINQTLAEVI TEQANLSVSA AHSSKVLYVI TSSPSHPPQT VPGSHSWVPS VGASGHRVEG WT. It is sometimes possible for the material contained within the vial of "Kremen protein 1 (Kremen1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
