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SDS-Page

KLRC1 recombinant protein

KLRC1, 94-233aa, Human, His-tag, Baculovirus

Gene Names
KLRC1; NKG2; NKG2A; CD159A
Applications
SDS-Page
Purity
> 90% by SDS-PAGE
Synonyms
KLRC1; 94-233aa; Human; His-tag; Baculovirus; NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A; CD159A; NKG2; NKG2A; KLRC1 recombinant protein
Ordering
For Research Use Only!
Host
Baculovirus
Purity/Purification
> 90% by SDS-PAGE
Form/Format
Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
Concentration
0.25mg/ml (determined by Absorbance at 280nm) (varies by lot)
Sequence
ADPPSTLIQR HNNSSLNTRT QKARHCGHCP EEWITYSNSC YYIGKERRTW EESLLACTSK NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN SSHHPWVTMN GLAFKHEIKD SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKLHHHHHH
Sequence Length
233
Applicable Applications for KLRC1 recombinant protein
SDS-PAGE
Antigen Species
Human
Tag Information
His-tag
Endotoxin Level
< 1.0 EU per 1ug of protein (determined by LAL method)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

SDS-Page

SDS-Page
Related Product Information for KLRC1 recombinant protein
KLRC1, also known as NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A, is a member of the killer cell lectin-like receptor family. It associates with CD94 and is expressed on NK cells and some activated T cell populations. This protein functions as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Recombinant human KLRC1 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Categories/Family for KLRC1 recombinant protein
References
Harrison RJ., et al, (2010) Clin Exp Immunol. 161:306-314.; Rapaport AS., et al, (2015) Immunity. 43:1112-1124

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
17.1kDa (149aa) 18-28KDa (SDS-PAGE under reducing conditions.)
NCBI Official Full Name
NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A
NCBI Official Synonym Full Names
killer cell lectin like receptor C1
NCBI Official Symbol
KLRC1
NCBI Official Synonym Symbols
NKG2; NKG2A; CD159A
NCBI Protein Information
NKG2-A/NKG2-B type II integral membrane protein
UniProt Protein Name
NKG2-A/NKG2-B type II integral membrane protein
UniProt Gene Name
KLRC1
UniProt Synonym Gene Names
NKG2A

NCBI Description

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]

Uniprot Description

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Research Articles on KLRC1

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Product Notes

The KLRC1 klrc1 (Catalog #AAA206658) is a Recombinant Protein produced from Baculovirus and is intended for research purposes only. The product is available for immediate purchase. The tag for this protein is His-tag. AAA Biotech's KLRC1 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE. Researchers should empirically determine the suitability of the KLRC1 klrc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: ADPPSTLIQR HNNSSLNTRT QKARHCGHCP EEWITYSNSC YYIGKERRTW EESLLACTSK NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN SSHHPWVTMN GLAFKHEIKD SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKLHHHHHH. It is sometimes possible for the material contained within the vial of "KLRC1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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