KLK15 recombinant protein

KLK15, 17-256aa, Human, His-tag, Baculovirus

Cat. Num. AAA206580

• Gene Names: KLK15; ACO; HSRNASPH
• Applications: SDS-Page
• Purity: > 80% by SDS-PAGE
• Synonyms: KLK15; 17-256aa; Human; His-tag; Baculovirus; Kallikrein-15 isoform 4; ACO; HSRNASPH; KLK15 recombinant protein

• Host: Baculovirus
• Purity/Purification: > 80% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
• Concentration: 0.25mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence: ADPQDGDKLL EGDECAPHSQ PWQVALYERG RFNCGASLIS PHWVLSAAHC QSRFMRVRLG EHNLRKRDGP EQLRTTSRVI PHPRYEARSH RNDIMLLRLV QPARLNPQVR PAVLPTRCPH PGEACVVSGW GLVSHNEPGT AGSPRSQVSL PDTLHCANIS IISDTSCDKS YPGRLTNTMV CAGAEGRGAE SCEGDSGGPL VCGGILQGIV SWGDVPCDNT TKPGVYTKVC HYLEWIRETM KRNHHHHHH
• Sequence Length: 256

• Applicable Applications for KLK15 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for KLK15 recombinant protein

KLK15, also known as kallikrein-15 isoform 4, is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. Also, growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In prostate cancer, it has increased expression, which indicates its possible use as a prognostic marker for prostate cancer. Recombinant human KLK15, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for KLK15 recombinant protein

Signal Transduction; Enzymes & Proteases; Cytoskeleton

References

Mavridis K., et al, (2013) Prostate 73:1191-1201.; Yousef GM., et al, (2001) J. Biol. Chem. 276:53-61.

NCBI and Uniprot Product Information

• NCBI GI #: 20302143
• NCBI GeneID: 55554
• NCBI Accession #: NP_059979
• NCBI GenBank Nucleotide #: NM_017509.3
• UniProt Accession #: Q9H2R5; Q15358; Q6ISI0; Q9H2R3; Q9H2R4; Q9H2R6; Q9HBG9; A0AUY8
• Molecular Weight: 27.4kDa (249aa) 28-40kDa (SDS-PAGE under reducing conditions.)
• NCBI Official Full Name: kallikrein-15 isoform 4 preproprotein
• NCBI Official Synonym Full Names: kallikrein related peptidase 15
• NCBI Official Symbol: KLK15
• NCBI Official Synonym Symbols: ACO; HSRNASPH
• NCBI Protein Information: kallikrein-15
• UniProt Protein Name: Kallikrein-15
• Protein Family: Kallikrein
• UniProt Gene Name: KLK15

NCBI Description

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

Protease whose physiological substrate is not yet known.