KLK15 recombinant protein

KLK15 Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8121152

• Gene Names: KLK15; ACO; HSRNASPH
• Purity: >80% as determined by SDS-PAGE
• Synonyms: KLK15; KLK15 Protein; Human; Recombinant (hFc Tag); Human Kallikrein-15/KLK15 Protein (Fc Tag); ACO Protein; HSRNASPH Protein; kallikrein-related peptidase 15; KLK15 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >80% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asn256

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gln 17
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human KLK15 (NP_059979.2)(Met1-Asn256) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for KLK15 recombinant protein

Background: KLK15 (Kallikrein Related Peptidase 15) is a Protein Coding gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Human KLK15 may have some utility as a prostate, ovarian, and breast cancer biomarker, based on previous studies, which examined mRNA levels of KLK15. Aberrant KLK15 expression is found in breast, ovarian, and prostate cancers. KLK15 over-expression is reported to be a significant predictor of reduced progression-free survival and overall survival in ovarian cancer. Kallikrein 15 (KLK15)/Prostinogen is a plausible candidate for prostate cancer susceptibility. Elevated KLK15 expression has been reported in prostate cancer and it has been described as an unfavorable prognostic marker for the disease.

NCBI and Uniprot Product Information

• NCBI GI #: 20302143
• NCBI GeneID: 55554
• NCBI Accession #: NP_059979.2
• NCBI GenBank Nucleotide #: NM_017509.3
• Molecular Weight: 28,016 Da
• NCBI Official Full Name: kallikrein-15 isoform 4 preproprotein
• NCBI Official Synonym Full Names: kallikrein-related peptidase 15
• NCBI Official Symbol: KLK15
• NCBI Official Synonym Symbols: ACO; HSRNASPH
• NCBI Protein Information: kallikrein-15; ACO protease; kallikrein-like serine protease; prostinogen
• Protein Family: Kallikrein

NCBI Description

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]