Human killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 ELISA Kit | KIR3DL2 elisa kit
Human Killer cell immunoglobulin-like receptor 3DL2, KIR3DL2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
Uniprot Description
KIR3DL2: Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: integral to plasma membrane; plasma membrane
Biological Process: regulation of immune response; cellular defense response
Research Articles on KIR3DL2
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Product Notes
The Human KIR3DL2 kir3dl2 (Catalog #AAA9329655) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329655 ELISA Kit recognizes Human KIR3DL2. It is sometimes possible for the material contained within the vial of "killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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