Katanin p80 WD40-containing subunit B1 (Katnb1) Recombinant Protein | Katnb1 recombinant protein

Recombinant Mouse Katanin p80 WD40-containing subunit B1 (Katnb1)

Cat. Num. AAA1315424

• Gene Names: Katnb1; KAT; 2410003J24Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Katanin p80 WD40-containing subunit B1 (Katnb1); Recombinant Mouse Katanin p80 WD40-containing subunit B1 (Katnb1); Katnb1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-658, Full length protein
• Sequence: MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVTQDPVQANQPLTQQTPNPGVSLRRIYERPSTTCSKPQRVKHNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKNSISRTPPRRSEPFPAPPEDDAATVKEVSKPSPAMDVQLPQLPVPNLEVPARPSVMTSTPAPKGEPDIIPATRNEPIGLKASDFLPAVKVPQQAELVDEDAMSQIRKGHDTMFVVLTSRHKNLDTVRAVWTTGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSLKLILQRFLPLITDILAAPPSVGVDISREERLHKCRLCFKQLKSISGLVKSKSGLSGRHGSAFRELHLLMASLD
• Sequence Length: 658

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Katnb1 recombinant protein

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.

NCBI and Uniprot Product Information

• NCBI GI #: 84095201
• NCBI GeneID: 74187
• NCBI Accession #: NP_083081.2
• NCBI GenBank Nucleotide #: NM_028805.2
• UniProt Accession #: Q8BG40; Q8CD18; Q8R1J0; Q9CWV2
• Molecular Weight: 72,639 Da
• NCBI Official Full Name: katanin p80 WD40 repeat-containing subunit B1
• NCBI Official Synonym Full Names: katanin p80 (WD40-containing) subunit B 1
• NCBI Official Symbol: Katnb1
• NCBI Official Synonym Symbols: KAT; 2410003J24Rik
• NCBI Protein Information: katanin p80 WD40 repeat-containing subunit B1
• UniProt Protein Name: Katanin p80 WD40 repeat-containing subunit B1
• Protein Family: Katanin p80 WD40 repeat-containing
• UniProt Gene Name: Katnb1
• UniProt Synonym Gene Names: Katanin p80 subunit B1

Uniprot Description

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. The function in regulating microtubule dynamics at spindle poles seems to depend on the association of the katanin KATNA1:KATNB1 complex with ASPM which recruits it to microtubules. Reversely KATNA1:KATNB1 can enhance ASPM blocking activity on microtubule minus-end growth. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.