Katanin p60 ATPase-containing subunit A1 (KATNA1) Recombinant Protein | KATNA1 recombinant protein

Recombinant Human Katanin p60 ATPase-containing subunit A1 (KATNA1)

Cat. Num. AAA1246799

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Katanin p60 ATPase-containing subunit A1 (KATNA1); Recombinant Human Katanin p60 ATPase-containing subunit A1 (KATNA1); KATNA1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-491aa; Full Length
• Sequence: MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for KATNA1 recombinant protein

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.

NCBI and Uniprot Product Information

• NCBI GI #: 323276651
• NCBI GeneID: 11104
• NCBI Accession #: NP_001191005.1
• NCBI GenBank Nucleotide #: NM_001204076.1
• UniProt Accession #: O75449; Q5TFA8; Q5TFA9; Q86VN2; Q9NU52; E1P5A3
• Molecular Weight: 35,319 Da
• NCBI Official Full Name: katanin p60 ATPase-containing subunit A1 isoform 2
• NCBI Official Synonym Full Names: katanin catalytic subunit A1
• NCBI Official Symbol: KATNA1
• NCBI Protein Information: katanin p60 ATPase-containing subunit A1
• UniProt Protein Name: Katanin p60 ATPase-containing subunit A1
• UniProt Gene Name: KATNA1
• UniProt Synonym Gene Names: Katanin p60 subunit A1

NCBI Description

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]

Uniprot Description

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.