Western Blot (WB)
(KATNA1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KATNA1 antibody detected the KATNA1 protein (arrow).)
Rabbit KATNA1 Polyclonal Antibody | anti-KATNA1 antibody
KATNA1 Antibody (N-term)
Western Blot (WB)
(KATNA1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KATNA1 antibody detected the KATNA1 protein (arrow).)
Western Blot (WB)
(KATNA1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KATNA1 antibody detected the KATNA1 protein (arrow).)
form the mitotic spindle of a dividing cell and help to organize
membranous organelles during interphase. Katanin is a heterodimer
that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa
accessory protein (p80 subunit B 1). The p60 subunit acts to sever
and disassemble microtubules, while the p80 subunit targets the
enzyme to the centrosome. This gene encodes the p80 subunit. This
protein is a member of the AAA family of ATPases. [provided by
RefSeq].
Iwaya, N., et al. J. Biol. Chem. 285(22):16822-16829(2010)
Sudo, H., et al. Hum. Mol. Genet. 17(16):2524-2540(2008)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Buster, D., et al. J. Cell. Sci. 115 (PT 5), 1083-1092 (2002) :
NCBI and Uniprot Product Information
NCBI Description
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]
Uniprot Description
KATNA1: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays, such as during disassembly of interphase microtubules at the G2-M transition. May also be required for microtubule release from the centrosome after nucleation. In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux. In neurons, microtubule release within the cell body may allow their subsequent transport into neuronal processes by microtubule dependent motor proteins. This transport is required for axonal growth. Belongs to the AAA ATPase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.4.3; Motility/polarity/chemotaxis; Hydrolase
Chromosomal Location of Human Ortholog: 6q25.1
Cellular Component: spindle pole; centrosome; microtubule; lipid particle; nucleoplasm; growth cone; cell soma; axon; cytoplasm; plasma membrane; microtubule organizing center; spindle; midbody; nucleus
Molecular Function: dynein binding; protein binding; protein heterodimerization activity; microtubule binding; microtubule-severing ATPase activity; ATP binding
Biological Process: mitosis; protein localization; cell division; metabolic process; microtubule severing; neuron migration; microtubule bundle formation; cytoplasmic microtubule organization and biogenesis
Research Articles on KATNA1
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Product Notes
The KATNA1 katna1 (Catalog #AAA9209821) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 59-85. The KATNA1 Antibody (N-term) reacts with Human (Predicted Reactivity: Monkey) and may cross-react with other species as described in the data sheet. AAA Biotech's KATNA1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the KATNA1 katna1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KATNA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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