Chemical Structure
JHU 37160, Inhibitor | JHU37160, inhibitor
JHU 37160
Purity
0.9925
Synonyms
JHU 37160; JHU37160; inhibitor
Purity/Purification
0.9925
Form/Format
Solid
Solubility
Ethanol: 72mg/mL (200.65mM)
DMSO: 72mg/mL (200.65mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
DMSO: 72mg/mL (200.65mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
FC1=C2NC3=CC=C(Cl)C=C3N=C(N4CCN(CC)CC4)C2=CC=C1
Formula
C19H20ClFN4
In vitro
JHU 37160 exhibits high in vivo DREADD potency. It exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice
CAS Number
2369979-68-8
Preparation and Storage
Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).
Chemical Structure
Chemical Structure
Related Product Information for JHU37160, inhibitor
JHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 and 3.6 for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 and 0.2 for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
Product Categories/Family for JHU37160, inhibitor
References
Bonaventura J, Eldridge M, Hu F, et al. High-potency ligands for DREADD imaging and activation in rodents and monkeys[J]. Nature Communications, 2019, 10(1).
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Product Notes
The JHU37160 (Catalog #AAA5765141) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "JHU 37160, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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