Chemical Structure
HS 014 acetate, Inhibitor | HS014, inhibitor
HS 014 acetate (207678-81-7 free base)
Purity
100.0%
Synonyms
HS 014 acetate; HS 014 acetate (207678-81-7 free base); HS014; inhibitor
Purity/Purification
100.0%
Form/Format
Solid
Solubility
DMSO: 10mM
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
CC(N[C@H]1CSSC[C@@H](C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@H](C(N[C@H](C(N)=O)CC(O)=O)=O)CCCCN)=O)=O)=O)NC(CNC([C@H](CC4=CNC5=CC=CC=C54)NC([C@H](CCCNC(N)=N)NC([C@@H](CC6=CC7=CC=CC=C7C=C6)NC([C@H](CC8=CNC=N8)NC([C@H](CCC(O)=O)NC1=O)=O)=O)=O)=O)=O)=O)=O.O=C(C)O
Formula
C73H98N20O19S2
Preparation and Storage
Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).
Chemical Structure
Chemical Structure
Related Product Information for HS014, inhibitor
HS 014 acetate is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16,108,54.4 and 694 for cloned human MC4,MC1,MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1beta-induced Fos expression in the paraventricular hypothalamus.
Product Categories/Family for HS014, inhibitor
References
Bellasio et al (2003) Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 482 127 PMID:
Schioth et al (1998) Discovery of novel melanocortin4 receptor selective MSH analogues. Br.J.Pharmacol. 124 75 PMID:
Whitaker and Reye (2008) Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1beta administration. Neuropharmacology 54 509 PMID:
Schioth et al (1998) Discovery of novel melanocortin4 receptor selective MSH analogues. Br.J.Pharmacol. 124 75 PMID:
Whitaker and Reye (2008) Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1beta administration. Neuropharmacology 54 509 PMID:
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Product Notes
The HS014 (Catalog #AAA5765507) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HS 014 acetate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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