Integrin beta-5 Extracellular Domain (ED) Recombinant Protein | ITGB5 recombinant protein

Human CellExp Integrin beta-5 Extracellular Domain (ED), Human Recombinant

Cat. Num. AAA849799

• Purity: >95% by SDS-PAGE
• Synonyms: Integrin beta-5 Extracellular Domain (ED); Human CellExp Integrin beta-5 Extracellular Domain (ED); Human Recombinant; ITGB5; integrin subunit beta 5; integrin beta 5; ITGB5 recombinant protein

• Host: HEK293 cells
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Lyophilized from 0.22 um filtered solution in PBS pH7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.

• Gene Source: Human
• Reconstitution Instruction: Reconstitute in sterile deionized water to the desired protein concentration.
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

SDS-Page

Related Product Information for ITGB5 recombinant protein

Integrins are a family of cell surface transmembrane receptors, each consisting of an alpha and a beta subunit that bind to extracellular matrix (ECM) proteins and cellular counter receptors and associate with the cytoskeleton. In mammals, 24 different integrins are generated through different combinations of 18 alpha and 8 beta subunits. A number of human congenital disorders have been associated with defective integrin-mediated adhesion, including the blistering disorder junctional epidermolysis bullosa, the bleeding disorder Glanzmann's thrombastenia, leukocyte adhesion deficiency-I (beta2 integrins in leukocytes) and leukocyte adhesion deficiency-III, nephrotic syndrome and interstitial lung disease and muscular dystrophy. Integrin alpha-V/beta-5 is a receptor for fibronectin and it recognizes the sequence R-G-D in its ligand. Receptor for fibronectin and adenovirus type C

Product Categories/Family for ITGB5 recombinant protein

Proteins; Enzymes; Human cell expressed recombinant proteins; Proteins & Enzymes (A-Z)

NCBI and Uniprot Product Information

• NCBI GI #: 20127446
• NCBI GeneID: 3693
• NCBI Accession #: NP_002204.2
• NCBI GenBank Nucleotide #: NM_002213.3
• UniProt Accession #: P18084; B0LPF8; B2RD70
• Molecular Weight: 88,054 Da
• NCBI Official Full Name: integrin beta-5
• NCBI Official Synonym Full Names: integrin, beta 5
• NCBI Official Symbol: ITGB5
• NCBI Protein Information: integrin beta-5
• UniProt Protein Name: Integrin beta-5
• Protein Family: Integrin
• UniProt Gene Name: ITGB5
• UniProt Entry Name: ITB5_HUMAN

Uniprot Description

ITGB5: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Belongs to the integrin beta chain family.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q21.2

Cellular Component: focal adhesion; cell surface; leading edge; plasma membrane; phagocytic vesicle; receptor complex

Molecular Function: integrin binding; protein binding; receptor activity

Biological Process: integrin-mediated signaling pathway; antigen processing and presentation of peptide antigen via MHC class I; extracellular matrix organization and biogenesis; muscle contraction; transforming growth factor beta receptor signaling pathway; cell-matrix adhesion; stress fiber formation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I