Integrin alpha 6 beta 1 Heterodimer Recombinant Protein | ITGA6 recombinant protein

Human CellExp Integrin alpha 6 beta 1 Heterodimer, Human Recombinant

Cat. Num. AAA849830

• Gene Names: ITGA6; CD49f; VLA-6; ITGA6B
• Purity: >90% by SDS-PAGE
• Synonyms: Integrin alpha 6 beta 1 Heterodimer; Human CellExp Integrin alpha 6 beta 1 Heterodimer; Human Recombinant; Integrin alpha 6 beta 1; ITGA6B1; ITGA6&ITGB1; CD49f; VLA-6; ITGA6 recombinant protein

• Host: HEK293 cells
• Purity/Purification: >90% by SDS-PAGE
• Form/Format: Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

• Gene Source: Human
• Endotoxin: <1.0 EU per/ug
• Reconstitution Instruction: Reconstitute in sterile deionized water to the desired protein concentration.
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

SDS-Page

Related Product Information for ITGA6 recombinant protein

Integrin alpha 6 beta 1, also called platelet glycoprotein GPIc-IIa, is a receptor for laminin on platelets. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. ITGA6 has been shown to interact with TSPAN4 and GIPC1.

Product Categories/Family for ITGA6 recombinant protein

Proteins; Enzymes; Human cell expressed recombinant proteins; Proteins & Enzymes (A-Z)

NCBI and Uniprot Product Information

• NCBI GI #: 119395742
• NCBI GeneID: 3655
• NCBI Accession #: NP_000201.2
• NCBI GenBank Nucleotide #: NM_000210.2
• UniProt Accession #: P23229; P05556
• Molecular Weight: 126,633 Da
• NCBI Official Full Name: integrin alpha-6 isoform b
• NCBI Official Synonym Full Names: integrin, alpha 6
• NCBI Official Symbol: ITGA6
• NCBI Official Synonym Symbols: CD49f; VLA-6; ITGA6B
• NCBI Protein Information: integrin alpha-6; integrin alpha6B; CD49 antigen-like family member F
• UniProt Protein Name: Integrin alpha-6
• Protein Family: Integrin
• UniProt Gene Name: ITGA6
• UniProt Entry Name: ITA6_HUMAN

NCBI Description

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ITGA6: Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Belongs to the integrin alpha chain family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: cell surface; cell-cell adherens junction; focal adhesion; hemidesmosome; plasma membrane; basal plasma membrane; basement membrane; filopodium; external side of plasma membrane

Molecular Function: integrin binding; protein binding; metal ion binding; laminin binding

Biological Process: integrin-mediated signaling pathway; skin development; extracellular matrix organization and biogenesis; filopodium formation; positive regulation of apoptosis; cell-matrix adhesion; cell-substrate adhesion; cell-cell adhesion; hemidesmosome assembly; gut development; cellular response to extracellular stimulus; brown fat cell differentiation; positive regulation of cell-cell adhesion; cell-substrate junction assembly; cell adhesion mediated by integrin; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; leukocyte migration; positive regulation of phosphorylation

Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia