Integrin beta-3 (Itgb3) Recombinant Protein | Itgb3 recombinant protein
Recombinant Mouse Integrin beta-3 (Itgb3)
NCBI and Uniprot Product Information
Uniprot Description
ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: filopodium membrane; focal adhesion; cell surface; integral to membrane; cell projection; membrane; microvillus membrane; apical plasma membrane; plasma membrane; melanosome; nucleus; cell junction; integrin complex; receptor complex; external side of plasma membrane
Molecular Function: integrin binding; identical protein binding; protein binding; protease binding; vascular endothelial growth factor receptor 2 binding; extracellular matrix binding; fibronectin binding; protein disulfide isomerase activity; cell adhesion molecule binding; receptor activity; peptide binding
Biological Process: negative regulation of lipid transport; entry of virus into host cell; protein folding; positive regulation of osteoclast differentiation; multicellular organismal development; positive regulation of leukocyte migration; positive regulation of smooth muscle cell proliferation; cell-matrix adhesion; smooth muscle cell migration; negative chemotaxis; positive regulation of smooth muscle cell migration; regulation of cell migration; positive regulation of MAPKKK cascade; cell-substrate junction assembly; positive regulation of bone resorption; cell adhesion; cell growth; integrin-mediated signaling pathway; platelet activation; cell migration; negative regulation of lipoprotein metabolic process; positive regulation of cell adhesion mediated by integrin; cell projection morphogenesis; angiogenesis involved in wound healing; regulation of release of sequestered calcium ion into cytosol; cell-substrate adhesion; cellular calcium ion homeostasis; heterotypic cell-cell adhesion; positive regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of osteoblast proliferation; activation of protein kinase activity; positive regulation of endothelial cell proliferation; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of cell migration
Research Articles on Itgb3
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Product Notes
The Itgb3 itgb3 (Catalog #AAA1170191) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 26-717. The amino acid sequence is listed below: ESNIC TTRGVNSCQQ CLAVSPVCAW CSDETLSQGS PRCNLKENLL KDNCAPESIE FPVSEAQILE ARPLSSKGSG SSAQITQVSP QRIALRLRPD DSKIFSLQVR QVEDYPVDIY YLMDLSFSMK DDLSSIQTLG TKLASQMRKL TSNLRIGFGA FVDKPVSPYM YISPPQAIKN PCYNMKNACL PMFGYKHVLT LTDQVSRFNE EVKKQSVSRN RDAPEGGFDA IMQATVCDEK IGWRNDASHL LVFTTDAKTH IALDGRLAGI VLPNDGHCHI GTDNHYSAST TMDYPSLGLM TEKLSQKNIN LIFAVTENVV SLYQNYSELI PGTTVGVLSD DSSNVLQLIV DAYGKIRSKV ELEVRDLPEE LSLSFNATCL NNEVIPGLKS CVGLKIGDTV SFSIEAKVRG CPQEKEQSFT IKPVGFKDSL TVQVTFDCDC ACQAFAQPSS PRCNNGNGTF ECGVCRCDQG WLGSMCECSE EDYRPSQQEE CSPKEGQPIC SQRGECLCGQ CVCHSSDFGK ITGKYCECDD FSCVRYKGEM CSGHGQCNCG DCVCDSDWTG YYCNCTTRTD TCMSTNGLLC SGRGNCECGS CVCVQPGSYG DTCEKCPTCP DACSFKKECV ECKKFNRGTL HEENTCSRYC RDDIEQVKEL TDTGKNAVNC TYKNEDDCVV RFQYYEDTSG RAVLYVVEEP ECPKGPD. It is sometimes possible for the material contained within the vial of "Integrin beta-3 (Itgb3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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