Testing Data
PlGF active protein
Mouse PlGF
Gene Names
Pgf; PIGF; Plgf; AI854365
Reactivity
Mouse
Purity
> 95% by SDS-PAGE & silver stain
Synonyms
PlGF; Mouse PlGF; Recombinant Mouse Placenta Growth Factor; Placenta Growth Factor; PlGF active protein
Host
Insect Cells
Reactivity
Mouse
Purity/Purification
> 95% by SDS-PAGE & silver stain
Form/Format
Freeze dried
Sequence
N-Terminal Sequence: ALSAGNNSTE AND AGNNSTE
Sequence Length
135 / 132
N Terminal Sequence
ALSAGNNSTE and AGNNSTE
Buffer
25 mM Tris, 75 mM NaCl pH 8.5
Preparation and Storage
The lyophilized mouse PIGF, though stable at room temperature, is best stored in working aliquots at -20 degree C to -70 degree C.
Testing Data
Testing Data
Testing Data #2
Testing Data #2
Related Product Information for PlGF active protein
Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family of growth factors. PlGF and VEGF share primary structural as well as limited amino acid sequence homology with the A and B chains of PDGF. All eight cysteine residues involved in intra and interchain disulfides are conserved among these growth factors. As a result of alternative splicing, three PlGF RNAs encoding monomeric human PlGF-1, PlGF-2 and PlGF-3 isoform precursors containing 149, 179 and 219 amino acid residues, respectively, have been described. In normal mouse tissues, only one mouse PlGF mRNA encoding the equivalent of human PlGF-2 has been identified. Mouse PlGF shares 65% amino acid identity with human PlGF-2. The gene for PlGF has been mapped to mouse chromosome 12 and human chromosome 14. PlGF binds with high affinity to Flt1, but not to Flk1/KDR.
Product Categories/Family for PlGF active protein
References
1. DiPalma, T. et al. (1996) Mamm. Genome 7:6. 2. Cao, Y. et al. (1997) Biochem. Biophys. Res. Commun. 235:493. 3. Ferrara, N. et al. (1997) Endocrin. Rev. 18:4
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 40 kDa (Dimer)
NCBI Official Full Name
placenta growth factor isoform 1
NCBI Official Synonym Full Names
placental growth factor
NCBI Official Symbol
Pgf
NCBI Official Synonym Symbols
PIGF; Plgf; AI854365
NCBI Protein Information
placenta growth factor
UniProt Protein Name
Placenta growth factor
UniProt Gene Name
Pgf
UniProt Synonym Gene Names
Plgf; PlGF
UniProt Entry Name
PLGF_MOUSE
Uniprot Description
Function: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth
By similarity.
Subunit structure: Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF
By similarity.
Subcellular location: Secreted
By similarity.
Sequence similarities: Belongs to the PDGF/VEGF growth factor family.
Research Articles on PlGF
Similar Products
Product Notes
The PlGF pgf (Catalog #AAA691520) is an Active Protein produced from Insect Cells and is intended for research purposes only. The product is available for immediate purchase. The Mouse PlGF reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: N-Terminal Sequence: ALSAGNNSTE AND AGNNSTE. It is sometimes possible for the material contained within the vial of "PlGF, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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