HGF active protein

Mouse HGF

Cat. Num. AAA692068

• Gene Names: Hgf; SF; NK1; NK2; HGF/SF; SF/HGF; C230052L06Rik
• Reactivity: Mouse
• Purity: > 95% by SDS-PAGE & HPLC analyses
• Synonyms: HGF; Mouse HGF; Recombinant Murine MIP-3 alpha (CCL20); HGF active protein

• Host: Insect Cells
• Reactivity: Mouse
• Purity/Purification: > 95% by SDS-PAGE & HPLC analyses
• Form/Format: Lyophilized
• Sequence: Alpha chain: QKKRRNTLHE FKKSAKTTLT KEDPLLKIKT KKVN SADECA NRCIRNRGFT FTCKAFVFDK SRKRCYWYPF NSMSSGVKKG FGHEFDLYEN KDYIRNCIIG KGGSYKGTVS ITKSGIKCQP WNSMI PHEHS FLPSSYRGKD LQENYCRNPR GEEGGPWCFT SNPEVRYEVC DIPQCSEVEC MTCNGESYRG PMDHTESGKT CQRWDQQTPH RHKFLP ERYP DKGFDDNYCR NPDGKPRPWC YTLDPDTPWE YCAIKTCAHS A VNETDVPME TTECIQGQGE GYRGTSNTIW NGIPCQRWDS QYPHKHD ITP ENFKCKDLRE NYCRNPDGAE SPWCFTTDPN IRVGYCSQIP KC DVSSGQDC YRGNGKNYMG NLSKTRSGLT CSMWDKNMED LHRHIFWE PD ASKLNKNYCR NPDDDAHGPW CYTGNPLIPW DYCPISRCEG DTT PTIVNLD HPVISCAKTK QLR Beta chain: VVNGIPTQTT VGWM VSLKYR NKHICGGSLI KESWVLTARQ CFPARNKDLK DYEAWLGIHD VHERGEEKRK QILNISQLVY GPEGSDLVLL KLARPAILDN FVSTI DLPSY GCTIPEKTTC SIYGWGYTGL INADGLLRVA HLYIMGNEKC SQHHQGKVTL NESELCAGAE KIGSGPCEGD YGGPLICEQH KMRMVL GVIV PGRGCAIPNR PGIFVRVAYY AKWIHKVILT YKL
• Sequence Length: 728

• Biological Activity: Determined by the dose-dependent stimulation of the proliferation of mouse IMCD3 cells using a concentration range of 10-20 ng/ml.

Related Product Information for HGF active protein

HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Murine HGF is expressed as a linear 728 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (alpha-chain and beta-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The alpha-chain consists of 463 amino acid residues and four kringle domains. The beta-chain consists of 233 amino acid residues.

Product Categories/Family for HGF active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 170172522
• NCBI GeneID: 15234
• NCBI Accession #: NP_034557.3
• NCBI GenBank Nucleotide #: NM_010427.5
• UniProt Accession #: Q08048; O55027; Q53WS5; Q61662; Q64007; Q6LBE6
• Molecular Weight: 82,945 Da
• NCBI Official Full Name: hepatocyte growth factor isoform 1 preproprotein
• NCBI Official Synonym Full Names: hepatocyte growth factor
• NCBI Official Symbol: Hgf
• NCBI Official Synonym Symbols: SF; NK1; NK2; HGF/SF; SF/HGF; C230052L06Rik
• NCBI Protein Information: hepatocyte growth factor; scatter factor; hepatopoietin-A
• UniProt Protein Name: Hepatocyte growth factor
• Protein Family: Hepatocyte growth factor
• UniProt Gene Name: Hgf
• UniProt Synonym Gene Names: SF
• UniProt Entry Name: HGF_MOUSE

Uniprot Description

Function: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Ref.13

Subunit structure: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.

Sequence similarities: Belongs to the peptidase S1 family. Plasminogen subfamily.Contains 4 kringle domains.Contains 1 PAN domain.Contains 1 peptidase S1 domain.

Caution: Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.

Sequence caution: The sequence CAA51054.1 differs from that shown. Reason: Erroneous initiation.