Structure
WNK463, Inhibitor
WNK463
Purity
>98% (HPLC)
Synonyms
WNK463; WNK-463; WNK 463; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=30mg/mL
Target
WNK Kinase
Receptor
WNK
Chemical Name
1H-Imidazole-5-carboxamide, N-(1, 1-dimethylethyl)-1-[1-[5-[5-(trifluoromethyl)-1, 3, 4-oxadiazol-2-yl]-2-pyridinyl]-4-piperidinyl]
SMILES
O=C(C1=CN=CN1C2CCN(C3=NC=C(C4=NN=C(C(F)(F)F)O4)C=C3)CC2)NC(C)(C)C
Molecular Formula
C21H24F3N7O2
CAS Number
2012607-27-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for WNK463, inhibitor
The first, potent, selective, and orally bioavailable pan With-No-Lysine (WNK) Kinase catalytic activity inhibitor with IC50 of 5/1/6/9nM for WNK1/2/3/4, respectively; shows >50% inhibition against only 2 out of 442 human kinases at 10uM; affects blood pressure and body fluid and electro-lyte homeostasis in rodent models of hypertension.
References
1. Yamada K, et al. Nat Chem Biol. 2016 Nov; 12 (11):896-898.
2. Zhang J, et al. Sci Signal. 2016 Oct 18; 9 (450):pe3.
2. Zhang J, et al. Sci Signal. 2016 Oct 18; 9 (450):pe3.
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Product Notes
The WNK463 (Catalog #AAA3603138) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "WNK463, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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