Structure
Vatalanib, Inhibitor
Vatalanib
Purity
>98% (HPLC)
Synonyms
Vatalanib; PTK787; PTK/ZK; CGP-79787D; CGP-79787; ZK-222584; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
VEGFR
Receptor
PDGFRbeta; VEGFR1/FLT1; VEGFR2/Flk1; VEGFR2/KDR; VEGFR3/FLT4
Chemical Name
1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, hydrochloride(1:2)
SMILES
ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=C2C=CC=C4)C=C1.[H]Cl.[H]Cl
Molecular Formula
C20H17Cl3N4
CAS Number
212141-51-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Vatalanib, inhibitor
A potent, orally available class III receptor tyrosine kinases inhibitor with IC50 of <1uM for VEGFR, Flt-1, KDR and PDGFRbeta; shows no activity against EGFR, FGFR-1, c-Met, and Tie-2, or c-Src, c-Abl, and PKC-alpha; blocks the VEGF-induced receptor autophosphorylation in CHO cells ectopically expressing the KDR receptor with IC50 of 34 nM; inhibits EGF and PDGF-induced angiogenesis in a growth factor implant model (25-100mg/kg). Ovarian Cancer Phase 1 Discontinued
Product Categories/Family for Vatalanib, inhibitor
References
1. Bold G, et al. J Med Chem. 2000 Jun 15; 43 (12):2310-23.
2. Wood JM, et al. Cancer Res. 2000 Apr 15; 60 (8):2178-89.
3. Drevs J, et al. Cancer Res. 2000 Sep 1; 60 (17):4819-24.
4. Hess C, et al. Br J Cancer. 2001 Dec 14; 85 (12):2010-6.
2. Wood JM, et al. Cancer Res. 2000 Apr 15; 60 (8):2178-89.
3. Drevs J, et al. Cancer Res. 2000 Sep 1; 60 (17):4819-24.
4. Hess C, et al. Br J Cancer. 2001 Dec 14; 85 (12):2010-6.
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Product Notes
The Vatalanib (Catalog #AAA3603374) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Vatalanib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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