Structure
OSI-930, Inhibitor
OSI-930
Purity
>98% (HPLC)
Synonyms
OSI-930; OSI 930; OSI930; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
c-Kit
Receptor
C-Raf; CSF-1R; FLT1; Lck; VEGFR2 (KDR)
Chemical Name
2-Thiophenecarboxamide, 3-[(4-quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]
SMILES
O=C(C1=C(NCC2=CC=NC3=CC=CC=C23)C=CS1)NC4=CC=C(OC(F)(F)F)C=C4
Molecular Formula
C22H16F3N3O2S
CAS Number
728033-96-3
Pathway
Angiogenesis
Preparation and Storage
Store at -20°C
Stability: >=2 years
Stability: >=2 years
Structure
Structure
Related Product Information for OSI-930, inhibitor
A potent, orally active, dual inhibitor of c-Kit and VEGFR-2 (KDR) with IC50 of 15nM and 9nM, respectively; also inhibits Lck, c-Raf, Flt1, and CSF-1R (IC50<100 nM); exhibits antitumor activity in mutant Kit-expressing HMC-1 xenograft model. Solid Tumors Phase 1 discontinued.
Product Categories/Family for OSI-930, inhibitor
References
1. Garton AJ, et al. Cancer Res. 2006 Jan 15; 66 (2):1015-24.
2. Yap TA, et al. Clin Cancer Res. 2013 Feb 15; 19 (4):909-19.
3. Patel JP, et al. Bioorg Med Chem Lett. 2011 Nov 1; 21 (21):6495-9.
4. Macpherson IR, et al. Eur J Cancer. 2013 Mar; 49 (4):782-9.
2. Yap TA, et al. Clin Cancer Res. 2013 Feb 15; 19 (4):909-19.
3. Patel JP, et al. Bioorg Med Chem Lett. 2011 Nov 1; 21 (21):6495-9.
4. Macpherson IR, et al. Eur J Cancer. 2013 Mar; 49 (4):782-9.
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Product Notes
The OSI-930 (Catalog #AAA3605783) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "OSI-930, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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