Structure
TRX-0237 Methylate, Inhibitor
TRX-0237 Methylate
Purity
>98% (HPLC)
Synonyms
TRX-0237 Methylate; LMTX; Hydromethylthionine; Methylene blue; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
H2O: >=31mg/mL (64.91mM)
Target
Amyloids
Receptor
Tau aggregation
Chemical Name
3, 7-bis(dimethylamino)phenothiazin-5-ium methanesulfonate
SMILES
CN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C.CS(=O)(=O)O.CS(=O)(=O)O
Molecular Formula
C17H21N3O3S2
CAS Number
1236208-20-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for TRX-0237 Methylate, inhibitor
TRX-0237 Methylate (LMTX) is a Tau aggregation inhibitor (TAI) with Ki of 0.12uM for intracellular TAI activity; disrupts paired helical filaments (PHFs) isolated from AD brain tissues at 0.16uM, delays cellular senescence and enhances key mitochondrial biochemical pathways; demonstrates activities in clinical trials in Alzheimer's disease (AD) with drugs targeting beta-amyloid accumulation in the brain. Alzheimer Disease Phase 3 Clinical
Product Categories/Family for TRX-0237 Methylate, inhibitor
References
1. Harrington CR, et al. J Biol Chem. 2015 Apr 24; 290 (17):10862-75.
2. Atamna H, et al. FASEB J. 2008 Mar; 22 (3):703-12.
3. Seripa D, et al. Expert Rev Neurother. 2016; 16 (3):259-77.
4. Wilcock GK, et al. J Alzheimers Dis. 2018; 61 (1):435-457.
2. Atamna H, et al. FASEB J. 2008 Mar; 22 (3):703-12.
3. Seripa D, et al. Expert Rev Neurother. 2016; 16 (3):259-77.
4. Wilcock GK, et al. J Alzheimers Dis. 2018; 61 (1):435-457.
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Product Notes
The TRX-0237 Methylate (Catalog #AAA3600950) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TRX-0237 Methylate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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