Testing Data
TAK-875, inhibitor
TAK-875
Synonyms
TAK-875; inhibitor
Solubility
DMSO >=105 mg/mL - Water <1 mg/mL - Ethanol >=11 mg/mL
Formula
C29H32O7S.1/2H2O
CAS Number
1000413-72-8
Preparation and Storage
Stable for; 2 years at -20 degree C Powder
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
Testing Data
Testing Data
Related Product Information for TAK-875, inhibitor
TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with an EC50 of 0.072 muM. TAK-875 is a new agent applied in the treatment of type 2 diabetes. TAK-875 not only elevated the levels of intra-cellular inositol monophosphate as well as calcium contents in rat insulinoma INS-1 833/15 cells but also improved the tolerance of glucose and amplified insulin secretion when orally administered in tolerance test. However, TAK-875 didn't increase the secretion of insulin and cause hypoglycemia when 30 mg/kg dosage of TAK-875 was given in fasted normal Sprague Dawley rats. Conversely, TAK-875 with a dosage of 10 mg/kg (p.o.) not only significantly improved plasma insulin levels but also decreased fasting hyperglycemia in male Zucker diabetic fatty rats. [1][2]
Product Categories/Family for TAK-875, inhibitor
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Product Notes
The TAK-875 (Catalog #AAA8506575) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TAK-875, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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