Testing Data
MLN 2238, inhibitor
MLN 2238
Synonyms
MLN 2238; inhibitor
Solubility
DMSO >=72 mg/mL - Water <1 mg/mL - Ethanol >=9 mg/mL
Formula
C14H19BCl2N2O4
CAS Number
1072833-77-2
Preparation and Storage
Stable for; 2 years at -20 degree C Powder
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
Testing Data
Testing Data
Related Product Information for MLN 2238, inhibitor
MLN2238 is a potent reversible and specific beta5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM. Proteasome activity was significantly inhibited in both blood and tumor following a single dose of MLN2238 administered IV at 14 mg/kg or SC at 4 mg/kg. Proteasome activity was inhibited greater than 50% for up to 8 hrs following the IV dose in both blood and tumor, whereas proteasome activity recovered more quickly following the SC dose. It is active in preclinical models of lymphoma, and that MLN2238 has antitumor activity in a model of lymphoma that is refractory to bortezomib treatment. [1][2]
Product Categories/Family for MLN 2238, inhibitor
References
http://ash.confex.com/ash/2009/webprogram/Paper20088.html http://ash.confex.com/ash/2009/webprogram/Paper20088.html; http://ash.confex.com/ash/2009/webprogram/Paper19135.html http://ash.confex.com/ash/2009/webprogram/Paper19135.html; The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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Product Notes
The MLN 2238 (Catalog #AAA8506503) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MLN 2238, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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