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Structure

SPOP-IN-6b, Inhibitor

SPOP-IN-6b

Purity
>98% (HPLC)
Synonyms
SPOP-IN-6b; SPOP IN-6b; SPOP IN 6b; inhibitor
Ordering
Purity/Purification
>98% (HPLC)
Target
E3 Ubiquitin Ligase
Receptor
E3 Ubiquitin Ligase
Chemical Name
2-imino-10-methyl-N-(3-morpholinopropyl)-5-oxo-1-phenethyl-1, 5-dihydro-2H-dipyrido[1, 2-a:2', 3'-d]pyrimidine-3-carboxamide
SMILES
O=C(C(C(N1CCC2=CC=CC=C2)=N)=CC3=C1N=C(C(C)=CC=C4)N4C3=O)NCCCN5CCOCC5
Molecular Formula
C28H32N6O3
CAS Number
2136270-20-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Structure

Structure
Related Product Information for SPOP-IN-6b, inhibitor
SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor that inhibits the SPOP-substrate protein interaction with IC50 of 35uM (inhibits puc-SBC1 peptide binding to SPOP); suppresses oncogenic SPOP-signaling pathways, and kills human ccRCC cells that are dependent on oncogenic cytoplasmic SPOP.
Product Categories/Family for SPOP-IN-6b, inhibitor
References
1. Guo ZQ, et al. Cancer Cell. 2016 Sep 12; 30 (3):474-484.

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Product Notes

The SPOP-IN-6b (Catalog #AAA3603403) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SPOP-IN-6b, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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