Structure
SNS-032, Inhibitor
SNS-032
Purity
>98% (HPLC)
Synonyms
SNS-032; BMS-387032; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
CDK
Receptor
CDK2/CyclinA; CDK2/CyclinE; CDK7/CyclinH; CDK9/CyclinT; GSK-3alpha
Chemical Name
4-Piperidinecarboxamide, N-[5-[[[5-(1, 1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]
SMILES
CC(C)(C)C1=CN=C(CSC2=CN=C(NC(=O)C3CCNCC3)S2)O1|t:4,6,10,12|
Molecular Formula
C17H24N4O2S2
CAS Number
345627-80-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SNS-032, inhibitor
SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48nM/62nM/4nM, respectively; displays 10- and 20-fold selective over CDK1/cycB and CDK4/cycD (IC50=480 and 925nM) respectively, and a panel of unrelated kinases, respectively; blocks the cell cycle via inhibition of CDKs 2 and 7, and transcription via inhibition of CDKs 7 and 9, has an A2780 cellular cytotoxicity assay IC50 of 95nM; exhibits a efficacy profile in A2780 human ovarian carcinoma xenograft model. Blood Cancer, Phase 2 Discontinued
Product Categories/Family for SNS-032, inhibitor
References
1. Misra RN, et al. J Med Chem. 2004 Mar 25; 47 (7):1719-28.
2. Mukhopadhyay P, et al. Cancer Res. 2006 Feb 1; 66 (3):1758-66.
3. Chen R, et al. Blood. 2009 May 7; 113 (19):4637-45.
4. Heath EI, et al. Invest New Drugs. 2008 Feb; 26 (1):59-65.
2. Mukhopadhyay P, et al. Cancer Res. 2006 Feb 1; 66 (3):1758-66.
3. Chen R, et al. Blood. 2009 May 7; 113 (19):4637-45.
4. Heath EI, et al. Invest New Drugs. 2008 Feb; 26 (1):59-65.
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Product Notes
The SNS-032 (Catalog #AAA3604182) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SNS-032, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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