Structure

SKLB1002, Inhibitor

SKLB1002

Purity

>98% (HPLC)

Synonyms

SKLB1002; SKLB 1002; inhibitor

Ordering
Cat. Num. AAA3607885 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Purity/Purification

>98% (HPLC)

Suitability

DMSO: 5.625mg/mL (17.56mM)

Target

Other Targets

Receptor

VEGFR2

Chemical Name

2-((6, 7-dimethoxyquinazolin-4-yl)thio)-5-methyl-1, 3, 4-thiadiazole

SMILES

COc1c(OC)cc2c(Sc3nnc(C)s3)ncnc2c1

Molecular Formula

C13H12N4O2S2

CAS Number

1225451-84-2

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Structure

Related Product Information for SKLB1002, inhibitor

SKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. Western blot analysis was conducted, which indicated that SKLB1002 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal-regulated kinase, focal adhesion kinase, and Src. In vivo zebrafish model experiments showed that SKLB1002 remarkably blocked the formation of intersegmental vessels in zebrafish embryos. SKLB1002 inhibits angiogenesis and may be a potential drug candidate in anticancer therapy.

Product Categories/Family for SKLB1002, inhibitor

Cancer

References

1. Zhang S, et al. Clin Y Res. 2011, 17 (13), 4439-4450.

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Product Notes

The SKLB1002 (Catalog #AAA3607885) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SKLB1002, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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SKLB1002, Inhibitor

SKLB1002

Structure

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