Structure
CH5132799, Inhibitor
CH5132799
Purity
>98% (HPLC)
Synonyms
CH5132799; CH-5132799; PA799; PA-799.; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 4.55mg/mL (12.06mM)
H2O: <0.1mg/mL
H2O: <0.1mg/mL
Target
DYRK
Receptor
mTOR; PI3Kalpha; PI3Kbeta; PI3Kgamma; PI3Kdelta
Chemical Name
5-(7-(methylsulfonyl)-2-morpholino-6, 7-dihydro-5H-pyrrolo[2, 3-d]pyrimidin-4-yl)pyrimidin-2-amine
SMILES
CS(=O)(=O)N1CCc2c(nc(nc12)N1CCOCC1)c1cnc(N)nc1
Molecular Formula
C15H19N7O3S
CAS Number
1007207-67-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CH5132799, inhibitor
CH5132799, also known as PA-799, is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3Kalpha (IC (50)=0.014uM). In human tumor cell lines with PI3K pathway activation, CH5132799 showed potent antiproliferative activity. CH5132799 is orally available and showed significant antitumor activity in PI3K pathway-activated human cancer xenograft models in mice. CH5132799 selectively inhibited class I PI3Ks and PI3Kalpha mutants in in vitro kinase assays. Tumors harboring PIK3CA mutations were significantly sensitive to CH5132799 in vitro and were remarkably regressed by CH5132799 in in vivo mouse xenograft models.
Product Categories/Family for CH5132799, inhibitor
References
1. Tanaka H, et al, Clin Y Res, 2011, 17 (10), 3272-3281.
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Product Notes
The CH5132799 (Catalog #AAA3607107) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CH5132799, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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