Shizukaol B, Inhibitor
Shizukaol B
Purity
98.00%
Synonyms
Shizukaol B; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C40H44O13
CAS Number
142279-40-1
Target & IC50
AP-1
COX
ERK
HIV
IL Receptor
JNK
NF-kappaB
NO
NOS
p38 MAPK
PGE
TNF-alpha
COX
ERK
HIV
IL Receptor
JNK
NF-kappaB
NO
NOS
p38 MAPK
PGE
TNF-alpha
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Shizukaol B, inhibitor
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells with relatively low cytotoxicity. Shizukaol B exhibits anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains, it also has significant cytotoxicities against C8166 cells. Shizukaol B prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha.
Product Categories/Family for Shizukaol B, inhibitor
References
Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells. Biomed Pharmacother. 2017 Apr;88:878-884
Sesquiterpenoids from Chloranthus henryi and their anti-neuroinflammatory activities. Chem Biodivers. 2014 Jun;11(6):919-28.
Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus. J Nat Prod. 2011 Jun 24;74(6):1408-13
Sesquiterpenoids from Chloranthus henryi and their anti-neuroinflammatory activities. Chem Biodivers. 2014 Jun;11(6):919-28.
Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus. J Nat Prod. 2011 Jun 24;74(6):1408-13
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Product Notes
The Shizukaol B (Catalog #AAA5763112) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Shizukaol B, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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