Structure
Pyroxamide, Inhibitor
Pyroxamide
Purity
98.77%
Synonyms
Pyroxamide; inhibitor
Purity/Purification
98.77%
Form/Format
Solid. Powder
Solubility
DMSO: 125mg/mL (471.15mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C13H19N3O3
SMILES
O=C(CCCCCCC(=O)Nc1cccnc1)NO
CAS Number
382180-17-8
Target & IC50
HDAC1: ic50 0.1-0.2uM
Cell Research
HDAC1 enzyme assay, A MEL cell line expressing the epitope DYKDDDDK-tagged HDAC1 was generated. HDAC1-DYKDDDDK was affinity purified by immunoprecipitation using M2 anti-DYKDDDDK antibody-coated agarose, followed by elution from the agarose using the DYKDDDDK peptide. [3H]acetate-labeled cellular histones were prepared from MEL cells and were used as a substrate for the HDAC activity assay. Released [3H]acetic acid was quantified by scintillation counting. For inhibition studies, the enzyme preparations were preincubated with pyroxamide (10 to 100,000nM) for 30 minutes at 4 degree C.[1]
In Vitro
Pyroxamide may be a useful agent for the treatment of malignancy and that induction of p21/WAF1 in transformed cells by pyroxamide may contribute to the antitumor effects of this agent[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for Pyroxamide, inhibitor
Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties (HDAC1;IC50: 0.1-0.2uM).
Product Categories/Family for Pyroxamide, inhibitor
References
Butler L M, Webb Y, Agus D B, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase[J]. Clinical Cancer Research, 2001, 7(4):962-970.
Butler L M, Webb Y, Agus D B, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase[J]. Clinical Cancer Research, 2001, 7(4):962-970.
Butler L M, Webb Y, Agus D B, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase[J]. Clinical Cancer Research, 2001, 7(4):962-970.
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Product Notes
The Pyroxamide (Catalog #AAA5758556) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Pyroxamide, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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