Structure
SW-100, inhibitor
SW-100
Purity
98.00%
Synonyms
SW-100; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 125mg/mL (394.60mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C17H17ClN2O2
SMILES
ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
CAS Number
2126744-35-0
Target & IC50
HDAC1: ic50 5.23uM
HDAC2: ic50 32.8uM
HDAC3: ic50 29.5uM
HDAC4: ic50 10.9uM
HDAC5: ic50 4.07uM
HDAC6: ic50 2.3nM
HDAC7: ic50 4.55uM
HDAC8: ic50 3.72uM
HDAC9: ic50 3.46uM
HDAC10: ic50 26.2uM
HDAC11: ic50 5.72uM
HDAC2: ic50 32.8uM
HDAC3: ic50 29.5uM
HDAC4: ic50 10.9uM
HDAC5: ic50 4.07uM
HDAC6: ic50 2.3nM
HDAC7: ic50 4.55uM
HDAC8: ic50 3.72uM
HDAC9: ic50 3.46uM
HDAC10: ic50 26.2uM
HDAC11: ic50 5.72uM
In Vitro
In mouse model of Fragile X syndrome, SW-100 (20mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing [1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for SW-100, inhibitor
SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the blood-brain-barrier.
Product Categories/Family for SW-100, inhibitor
References
Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695.
Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695.
Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695.
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Product Notes
The SW-100 (Catalog #AAA5755571) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SW-100, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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