Structure
LLL-12, Inhibitor
LLL-12
Purity
>98% (HPLC)
Synonyms
LLL-12; LLL12; LLL 12; inhibitor
Purity/Purification
>98% (HPLC)
Target
STAT
Receptor
STAT
Chemical Name
5-hydroxy-9, 10-dioxo-9, 10-dihydroanthracene-1-sulfonamide
SMILES
O=S(C(C=CC=C1C(C2=C3C=CC=C2O)=O)=C1C3=O)(N)=O
Molecular Formula
C14H9NO5S
CAS Number
1260247-42-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for LLL-12, inhibitor
A nonpeptide, cell-permeable STAT3 inhibitor that binds directly to the pTyr705 binding site of the STAT3 monomer; inhibit STAT3 phosphorylation (tyrosine 705) and induces apoptosis in various breast, pancreatic, and glioblastoma cancer cell lines with IC50 of 0.16-3.09uM; also inhibits STAT3 phosphorylation induced by IL-6 and IFN-alpha in MM cells, but not STAT1, STAT2, STAT4 and STAT6 phosphorylation; inhibits STAT3 DNA binding activity and STAT3-dependent transcriptional activity, but not STAT1; exhibits potent inhibitory activity on breast and glioblastoma tumor growth in a mouse xenograft model.
Product Categories/Family for LLL-12, inhibitor
References
1. Lin L, et al. Int J Cancer. 2012 Mar 15; 130 (6):1459-69.
2. Lin L, et al. Neoplasia. 2010 Jan; 12 (1):39-50.
3. Liu Y, et al. J Biol Chem. 2010 Aug 27; 285 (35):27429-39.
2. Lin L, et al. Neoplasia. 2010 Jan; 12 (1):39-50.
3. Liu Y, et al. J Biol Chem. 2010 Aug 27; 285 (35):27429-39.
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Product Notes
The LLL-12 (Catalog #AAA3601074) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LLL-12, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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