Structure
AC-4-130, Inhibitor
AC-4-130
Purity
>98% (HPLC)
Synonyms
AC-4-130; AC4130; AC-4130; AC4-130; inhibitor
Purity/Purification
>98% (HPLC)
Target
STAT
Receptor
STAT
Chemical Name
4-(2-((N-(4-chlorobenzyl)-2, 3, 4, 5, 6-pentafluorophenyl)sulfonamido)-N-(3, 5-di-tert-butylbenzyl)acetamido)benzoic acid
SMILES
FC1=C(F)C(F)=C(S(=O)(N(CC(N(CC2=CC(C(C)(C)C)=CC(C(C)(C)C)=C2)C3=CC=C(C(O)=O)C=C3)=O)CC4=CC=C(Cl)C=C4)=O)C(F)=C1F
Molecular Formula
C37H36ClF5N2O5S
CAS Number
1834571-82-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AC-4-130, inhibitor
AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3; disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription; substantially impairs the proliferation and clonogenic growth of human AML cell lines and primary FLT3-ITD+ AML patient cells in vitro and in vivo; synergistically increases the cytotoxicity of the JAK1/2 inhibitor Ruxolitinib and the p300/pCAF inhibitor Garcinol in vivo.
Product Categories/Family for AC-4-130, inhibitor
References
1. Wingelhofer B, et al. Leukemia. 2018 Feb 2. doi: 10.1038/s41375-017-0005-9.
Similar Products
Product Notes
The AC-4-130 (Catalog #AAA3602832) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AC-4-130, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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