Structure
PF-04620110, Inhibitor
PF-04620110
Purity
>98% (HPLC)
Synonyms
PF-04620110; PF 04620110; PF04620110; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
DGAT
Receptor
DGAT1
Chemical Name
Cyclohexaneacetic acid, 4-[4-(4-amino-7, 8-dihydro-5-oxopyrimido[5, 4-f][1, 4]oxazepin-6(5H)-yl)phenyl]-, trans
SMILES
C1CC(CCC1CC(=O)O)C2=CC=C(C=C2)N3CCOC4=NC=NC(=C4C3=O)N
Molecular Formula
C21H24N4O4
CAS Number
1109276-89-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PF-04620110, inhibitor
PF-04620110 is a potent, selective, orally bioavailable DGAT-1 inhibitor with IC50 of 19nM, shows no acitivity for DGAT-2 (IC50>30uM); shows high selectivity versus a broad panel of off-target pharmacologic end points; inhibits triglyceride synthesis of 3 in the intestinal-derived HT-29 cell line with IC50 of 8nM; demonstrates in vivo DGAT-1 inhibitionthrough reduction of plasma triglyceride levels in rodent, alters the temporal and spatial pattern of dietary lipid absorption in vivo. Diabetes Phase 1 Discontinued
Product Categories/Family for PF-04620110, inhibitor
References
1. Dow RL, et al. ACS Med Chem Lett. 2011 Mar 18; 2 (5):407-12.
2. Maciejewski BS, et al. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1; 304 (11):G958-69.
3. Maciejewski BS, et al. World J Gastrointest Pathophysiol. 2017 Nov 15; 8 (4):161-175.
2. Maciejewski BS, et al. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1; 304 (11):G958-69.
3. Maciejewski BS, et al. World J Gastrointest Pathophysiol. 2017 Nov 15; 8 (4):161-175.
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Product Notes
The PF-04620110 (Catalog #AAA3600407) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PF-04620110, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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