Structure
PF-04991532 Biochemical
PF-04991532
Purity
>98% (HPLC)
Synonyms
PF-04991532; PF4991532; PF-04991532 biochemical
Purity/Purification
>98% (HPLC)
Target
Glucokinase
Receptor
Glucokinase
Chemical Name
(S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid
SMILES
C1CCC(C1)CC(C(=O)NC2=NC=C(C=C2)C(=O)O)N3C=C(N=C3)C(F)(F)F
Molecular Formula
C18H19F3N4O3
CAS Number
1215197-37-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PF-04991532 biochemical
PF-04991532 (PF4991532) is a potent, hepatoselective Glucokinase (GK) activator with EC50 of 90 +/- 45nM; displays >50-fold liver-to-pancreas ratio of tissue distribution in rodent and non-rodent species; robustly lowers fasting and postprandial glucose with no hypoglycemia in vivo. DiabetesPhase 1 Discontinued
Product Categories/Family for PF-04991532 biochemical
References
1. Pfefferkorn JA, et al. J Med Chem. 2012 Feb 9; 55 (3):1318-33.
2. Erion DM, et al. PLoS One. 2014 May 23; 9 (5):e97139.
3. Ghosh A, et al. Drug Metab Dispos. 2014 Oct; 42 (10):1599-610.
2. Erion DM, et al. PLoS One. 2014 May 23; 9 (5):e97139.
3. Ghosh A, et al. Drug Metab Dispos. 2014 Oct; 42 (10):1599-610.
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Product Notes
The PF-04991532 (Catalog #AAA3600804) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PF-04991532, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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