Structure
MPT0E028, Inhibitor
MPT0E028
Purity
>98% (HPLC)
Synonyms
MPT0E028; MPT0 E028; inhibitor
Purity/Purification
>98% (HPLC)
Target
HDAC
Receptor
HDAC
Chemical Name
(E)-N-hydroxy-3-(1-(phenylsulfonyl)indolin-5-yl)acrylamide
SMILES
O=C(NO)/C=C/C1=CC2=C(N(S(=O)(C3=CC=CC=C3)=O)CC2)C=C1
Molecular Formula
C17H16N2O4S
CAS Number
1338320-94-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MPT0E028, inhibitor
MPT0E028 (MPT 0E028) is a potent HDAC inhibitor that inhibits nuclear HDAC activity with IC50 of 11.1nM in HeLa cells, 9-30 times more potent than SAHA; inhibits class I HDAC1, HDAC2, and class Iib HDAC6 with IC50 of 53, 106, and 29.5nM, respectively, weakly inhibits HDAC8 (IC50=2.5uM), but not for HDAC4 (IC50>10uM); inhibits the growth of HCT116 and MDA-MB-231 cells with IC50 of 0.09 and 0.19uM; inhibits HCT116 tumor xenograft in vivo without significant adverse effects, shows stronger anti-cancer efficacy than SAHA. Solid Tumors Phase 1 Clinical
Product Categories/Family for MPT0E028, inhibitor
References
1. Huang HL, et al. PLoS One. 2012; 7 (8):e43645.
2. Chen MC, et al. Cell Death Dis. 2013 Sep 19; 4:e810.
3. Chen CH, et al. Clin Cancer Res. 2014 Mar 1; 20 (5):1274-1287.
4. Huang HL, et al. Oncotarget. 2015 Mar 10; 6 (7):4976-91.
2. Chen MC, et al. Cell Death Dis. 2013 Sep 19; 4:e810.
3. Chen CH, et al. Clin Cancer Res. 2014 Mar 1; 20 (5):1274-1287.
4. Huang HL, et al. Oncotarget. 2015 Mar 10; 6 (7):4976-91.
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Product Notes
The MPT0E028 (Catalog #AAA3601358) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MPT0E028, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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