Structure
HDAC8-IN-22d, Inhibitor
HDAC8-IN-22d
Purity
>98% (HPLC)
Synonyms
HDAC8-IN-22d; HDAC8-IN-1; MDK-7933; MDK 7933; MDK7933; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 130mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
HDAC
Receptor
HDAC8
Chemical Name
(2E)-N-Hydroxy-3-(5-methoxy[1, 1':4', 1''-terphenyl]-2-yl)-2-propenamide
SMILES
ONC(/C=C/C1=CC=C(C=C1C2=CC=C(C=C2)C3=CC=CC=C3)OC)=O
Molecular Formula
C22H19NO3
CAS Number
1417997-93-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for HDAC8-IN-22d, inhibitor
HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2nM, exhibits no activity against other HDACs and limited activity against HDAC1 and 3; shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); exhibits cytotoxicity against human lung CL1-5 cells (IC50=7.0uM) similar to that of SAHA yet without significant cytotoxicity for normal IMR-90 cells.
Product Categories/Family for HDAC8-IN-22d, inhibitor
References
1. Huang WJ, et al. ChemMedChem. 2012 Oct; 7 (10):1815-24.
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Product Notes
The HDAC8-IN-22d (Catalog #AAA3601745) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HDAC8-IN-22d, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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