Crebinostat, Inhibitor

Crebinostat

• Purity: >98% (HPLC)
• Synonyms: Crebinostat; inhibitor

• Purity/Purification: >98% (HPLC)

• Target: HDAC
• Receptor: HDAC
• Chemical Name: Heptanoic acid, 7-(hydroxyamino)-7-oxo-, 2-([1, 1'-biphenyl]-4-ylmethylene)hydrazide
• SMILES: O=C(NO)CCCCCC(N/N=C/C1=CC=C(C2=CC=CC=C2)C=C1)=O
• Molecular Formula: C20H23N3O3
• CAS Number: 1092061-61-4
• Preparation and Storage: Store at -20 degree C; Stability: >=2 years; Shipping: Ice Pack

Structure

Related Product Information for Crebinostat, inhibitor

Crebinostat is a novel cognitive enhancer that inhibits class I HDAC/1/2/3 (IC50=0.7/1.0/2.0nM), class IIb HDAC6 (IC50=9.3nM) with weaker inhibition of the class I HDAC8 and no significant inhibition of the class IIa HDAC/4/5/7/9; potently induces acetylation of both histone H3 and histone H4 as well as enhanced the expression of the CREB target gene Egr1 in cultured mouse primary neurons; upregulates Bdnf and Grn, and downregulates Mapt (tau) gene expression-genes; brain penetrant.

Product Categories/Family for Crebinostat, inhibitor

Cell Cycle/DNA Damage

References

1. Fass DM, et al. Neuropharmacology. 2013 Jan; 64:81-96.
2. Ghosh B, et al. Bioorg Med Chem Lett. 2016 Feb 15; 26 (4):1265-71.