Structure
MK-591, Inhibitor
MK-591
Purity
>98% (HPLC)
Synonyms
MK-591; Quiflapon sodium; MK-0591; L-686708; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
FLAP
Receptor
FLAP
Chemical Name
1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1, 1-dimethylethyl)thio]-alpha, alpha-dimethyl-5-(2-quinolinylmethoxy)-, sodium salt(1:1)
SMILES
CC(C)(C)SC1=C(N(C2=C1C=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)CC5=CC=C(C=C5)Cl)CC(C)(C)C(=O)[O-].[Na+]
Molecular Formula
C34H34ClN2NaO3S
CAS Number
147030-01-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MK-591, inhibitor
A potent, orally active leukotriene biosynthesis inhibitor that acts by inhibiting 5-lipoxygenase activating protein (FLAP) with IC50 of 1.6nM in a FLAP binding assay; inhibits leukotriene (LT) biosynthesis in intact human and elicited rat PMNLs with IC50 of 3.1nM and 6.1nM, respectively; inhibits the systemic generation of peptidoleukotrienes as measured by urinary LTE4 excretion in dogs (ED50=1mg/kg). Asthma Phase 1 Discontinued
Product Categories/Family for MK-591, inhibitor
References
1. Brideau C, et al. Can J Physiol Pharmacol. 1992 Jun; 70 (6):799-807.
2. Mienard L, et al. Can J Physiol Pharmacol. 1992 Jun; 70 (6):808-13.
3. Tagari P, et al. J Pharmacol Exp Ther. 1993 Apr; 265 (1):416-25.
2. Mienard L, et al. Can J Physiol Pharmacol. 1992 Jun; 70 (6):808-13.
3. Tagari P, et al. J Pharmacol Exp Ther. 1993 Apr; 265 (1):416-25.
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Product Notes
The MK-591 (Catalog #AAA3602014) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MK-591, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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