Structure
GSK2190915, Inhibitor
GSK2190915
Purity
>98% (HPLC)
Synonyms
GSK2190915; AM-803; Fiboflapon; GSK-2190915; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
FLAP
Receptor
FLAP
Chemical Name
1H-Indole-2-propanoic acid, 3-[(1, 1-dimethylethyl)thio]-1-[[4-(6-ethoxy-3-pyridinyl)phenyl]methyl]-alpha, alpha-dimethyl-5-[(5-methyl-2-pyridinyl)methoxy]
SMILES
CCOC1=NC=C(C=C1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OCC5=NC=C(C=C5)C)C(=C3CC(C)(C)C(=O)O)SC(C)(C)C
Molecular Formula
C38H43N3O4S
CAS Number
936350-00-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GSK2190915, inhibitor
A potent, selective FLAP inhibitor with binding IC50 of 2.6nM; inhibits LTB4 synthesis following ionophore challenge in human whole blood with IC50 of 76nM (5 h incubation); shows good selectivity over CYP3A4, 2C9, and 2D6; exhibits excellent preclinical toxicology, pharmacokinetics and oral bioactivity. Asthma Phase 2 Clinical
Product Categories/Family for GSK2190915, inhibitor
References
1. Stock NS, et al. J Med Chem. 2011 Dec 8; 54 (23):8013-29.
2. Lorrain DS, et al. Eur J Pharmacol. 2010 Aug 25; 640 (1-3):211-8.
3. Kent SE, et al. Clin Exp Allergy. 2013 Feb; 43 (2):177-86.
2. Lorrain DS, et al. Eur J Pharmacol. 2010 Aug 25; 640 (1-3):211-8.
3. Kent SE, et al. Clin Exp Allergy. 2013 Feb; 43 (2):177-86.
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Product Notes
The GSK2190915 (Catalog #AAA3606696) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GSK2190915, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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