Structure
Vanoxerine, Inhibitor
Vanoxerine
Purity
>98% (HPLC)
Synonyms
Vanoxerine; Boxeprazine; GBR-12909; GBR12909; GBR 12909; I893; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Monoamine Transporter
Receptor
Monoamine Transporter
Chemical Name
Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)
SMILES
C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
Molecular Formula
C28H32F2N2O
CAS Number
67469-69-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Vanoxerine, inhibitor
Vanoxerine (GBR-12909, I-893, Boxeprazine) is a highly potent inhibitor of dopamine uptake in vitro in tissue slices obtained from rat neostriatum with IC50 of 40-50nM, also inhibits norepinephrine uptake with IC50 of 560-2600nM; Vanoxerine also is a potent hK (v)11.1 blocker, and at submicromolar concentrations, it blocks Ca and Na currents in a strongly frequency-dependent manner possesses anticonvulsant activity in zebrafish and rodent models of generalized epilepsy but with cardiac ion channel effects. Heart Arrhythmia Phase 3 Discontinued
Product Categories/Family for Vanoxerine, inhibitor
References
1. Teicher MH, et al. Brain Res. 1986 Nov; 395 (1):124-8.
2. Heikkila RE, et al. Eur J Pharmacol. 1984 Aug 17; 103 (3-4):241-8.
3. Lacerda AE, et al. J Cardiovasc Electrophysiol. 2010 Mar; 21 (3):301-10.
4. Goldsmith P, et al. Pharmacology. 2007; 79 (4):250-8.
2. Heikkila RE, et al. Eur J Pharmacol. 1984 Aug 17; 103 (3-4):241-8.
3. Lacerda AE, et al. J Cardiovasc Electrophysiol. 2010 Mar; 21 (3):301-10.
4. Goldsmith P, et al. Pharmacology. 2007; 79 (4):250-8.
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Product Notes
The Vanoxerine (Catalog #AAA3605573) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Vanoxerine, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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