Structure
MI-1481, Inhibitor
MI-1481
Purity
>98% (HPLC)
Synonyms
MI-1481; MI1481; inhibitor
Purity/Purification
>98% (HPLC)
Target
HMTase
Receptor
HMTase
Chemical Name
(S)-4methyl-1-((5-oxomorpholin-2-yl)methyl)-5-((4-((6-(2, 2, 2-trifluoroethyl)thieno[2, 3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile
SMILES
N#CC(N1C[C@@H](OC2)CNC2=O)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)CC4)=C3C
Molecular Formula
C29H30F3N7O2S
CAS Number
1887178-64-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MI-1481, inhibitor
MI-1481 (MI1481) is a highly potent inhibitor of the menin-MLL1 interaction with IC50 of 3.6nM, 10-fold increase in inhibitory activity over MI-463 and MI-503; markedly reduces cell growth of murine bone marrow cells transformed with MLL-AF9 with GI50 of 34nM, demonstrates potent on target activity in MLL leukemia cells with GI50 values of 36nM in MV4; 11 (harboring MLL-AF4 fusion protein) and 61nM in MOLM13 (harboring MLL-AF9); downregulates the MLL fusion protein target genes, HOXA9 and MEIS1, at 100nMin MV4; 11 human MLL leukemia cells; strongly inhibits leukemia progression in vivo.
Product Categories/Family for MI-1481, inhibitor
References
1. Borkin D, et al. J Med Chem. 2018 May 23. doi: 10.1021/acs.jmedchem.8b00071.
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Product Notes
The MI-1481 (Catalog #AAA3602955) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MI-1481, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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