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Structure

CPI-1205, Inhibitor

CPI-1205

Purity
>98% (HPLC)
Synonyms
CPI-1205; CPI 1205; CPI1205; inhibitor
Ordering
Purity/Purification
>98% (HPLC)
Target
HMTase
Receptor
HMTase
Chemical Name
(R)-N-((4-Methoxy-6-methyl-2-oxo-1, 2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2, 2, 2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
SMILES
C[C@@H](N1C2=C(C(C(NCC3=C(C=C(NC3=O)C)OC)=O)=C1C)C=CC=C2)C4CCN(CC(F)(F)F)CC4
Molecular Formula
C27H33F3N4O3
CAS Number
1621862-70-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Structure

Related Product Information for CPI-1205, inhibitor
A highly potent, selective EZH2 inhibitor with biochemical IC50 of 2nM, cellular EC50 of 32nM; demonstrates modest selectivity over EZH1 (IC50=52nM), and a clean selectivity profile against 30 other histone or DNA methyltransferases; exhibits robust antitumor effects in a Karpas-422 xenograft model (at 160mg/kg BID). Prostate Cancer Phase 2 Clinical
Product Categories/Family for CPI-1205, inhibitor
References
1. Vaswani RG, et al. J Med Chem. 2016 Nov 10; 59 (21):9928-9941.

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Product Notes

The CPI-1205 (Catalog #AAA3602387) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CPI-1205, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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