Structure
Lotamilast, Inhibitor
Lotamilast
Purity
>98% (HPLC)
Synonyms
Lotamilast; RVT 501; E6005; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
<1mg/mL refers to the product slightly soluble or insoluble
Target
PDE
Receptor
PDE4; PDE-4
Chemical Name
methyl 4-({3-[6, 7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate
SMILES
O=C(OC)C1=CC=C(C(NC2=CC=CC(C3=C4C=C(OC)C(OC)=CC4=NC(NC)=N3)=C2)=O)C=C1
Molecular Formula
C26H24N4O5
CAS Number
947620-48-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Lotamilast, inhibitor
Lotamilast (RVT 501, E6005) is apotent, selective PDE4 inhibitor with IC50 of 2.8nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1nM; produces an immediate antipruritic effect as well as an anti-inflammatory effect with reduced expression of cytokines/adhesion molecules in mice after topical application; ameliorates the appearance of atopic dermatitis-like skin lesions in AD models. Dermatitis Phase 2 Clinical
Product Categories/Family for Lotamilast, inhibitor
References
1. Ishii N, et al. J Pharmacol Exp Ther. 2013 Jul; 346 (1):105-12.
2. Andoh T, et al. Exp Dermatol. 2014 May; 23 (5):359-61.
3. Kubota S, et al. Eur J Pharmacol. 2015 Dec 5; 768:41-8.
4. Furue M, et al. Expert Opin Investig Drugs. 2017 Dec; 26 (12):1403-1408.
2. Andoh T, et al. Exp Dermatol. 2014 May; 23 (5):359-61.
3. Kubota S, et al. Eur J Pharmacol. 2015 Dec 5; 768:41-8.
4. Furue M, et al. Expert Opin Investig Drugs. 2017 Dec; 26 (12):1403-1408.
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Product Notes
The Lotamilast (Catalog #AAA3606783) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Lotamilast, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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