Structure
Apremilast, Inhibitor
Apremilast
Purity
>98% (HPLC)
Synonyms
Apremilast; CC 10004; CC10004; CC-10004; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
PDE
Receptor
PDE4
Chemical Name
Acetamide, N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2, 3-dihydro-1, 3-dioxo-1H-isoindol-4-yl]
SMILES
CC(NC1=CC=CC(C(N2[C@@H](C3=CC=C(OC)C(OCC)=C3)CS(=O)(C)=O)=O)=C1C2=O)=O
Molecular Formula
C22H24N2O7S
CAS Number
608141-41-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Apremilast, inhibitor
Apremilast (CC-10004) is a potent, orally active PDE4 inhibitor with IC50 of 74nM, inhibits TNF-alpha production in LPS-stimulated hPBMCs with IC50 of 77nM; inhibits PBMC production of the chemokines CXCL9 and CXCL10, IFN-gamma and TNF-alpha, and IL-2, IL-12 and IL-23, also inhibits TNF-alpha by NK cells and keratinocytes; significantly reduces epidermal thickness and proliferation, decreases the general histopathological appearance of psoriasiform features and reduces expression of TNF-alpha, human leukocyte antigen-DR and intercellular adhesion molecule-1 in the lesioned skin in model of psoriasis. Psoriasis Approved
Product Categories/Family for Apremilast, inhibitor
References
1. Man HW, et al. J Med Chem. 2009 Mar 26; 52 (6):1522-4.
2. McCann FE, et al. Arthritis Res Ther. 2010; 12 (3):R107.
3. Schafer PH, et al. Br J Pharmacol. 2010 Feb; 159 (4):842-55.
4. Gordon JN, et al. J Crohns Colitis. 2009 Sep; 3 (3):175-82.
2. McCann FE, et al. Arthritis Res Ther. 2010; 12 (3):R107.
3. Schafer PH, et al. Br J Pharmacol. 2010 Feb; 159 (4):842-55.
4. Gordon JN, et al. J Crohns Colitis. 2009 Sep; 3 (3):175-82.
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Product Notes
The Apremilast (Catalog #AAA3605282) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Apremilast, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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