Structure
C25-140, Inhibitor
C25-140
Purity
>98% (HPLC)
Synonyms
C25-140; TRAF6-Ubc13 inhibitor C25-140; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=130mg/mL (284.11mM)
Target
E2
Receptor
E2
Chemical Name
1-(4-benzylpiperidin-1-yl)-3-(3, 5-dimethyl-1-(3-methyl-[1, 2, 4]triazolo[4, 3-b]pyridazin-6-yl)-1H-pyrazol-4-yl)propan-1-one
SMILES
O=C(N1CCC(CC2=CC=CC=C2)CC1)CCC3=C(C)N(C4=NN5C(C=C4)=NN=C5C)N=C3C
Molecular Formula
C26H31N7O
CAS Number
1358099-18-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for C25-140, inhibitor
C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity; C25-140 effectively reduced TRAF6-mediated ubiquitin chain formation in vitro, impedes NF-kappaB activation in various immune and inflammatory signaling pathways also in primary human and murine cells; does not effect other E3 ligases (MDM2, TRIM63, ITCH, E6AP and RNF4), also does inhibit E1/E2 reactions.
Product Categories/Family for C25-140, inhibitor
References
1. Brenke JK, et al. J Biol Chem. 2018 Jun 27. pii: jbc.RA118.002649.
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Product Notes
The C25-140 (Catalog #AAA3601470) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "C25-140, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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