Structure
Rigosertib sodium, Inhibitor
Rigosertib sodium
Purity
>98% (HPLC)
Synonyms
Rigosertib sodium; ON-01910 sodium; ON01910 sodium; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
H2O: >=52mg/mL
Target
PLK
Receptor
PLK
Chemical Name
Glycine, N-[2-methoxy-5-[[[(1E)-2-(2, 4, 6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-, sodium salt(1:1)
SMILES
COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
Molecular Formula
C21H24NNaO8S
CAS Number
592542-60-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Rigosertib sodium, inhibitor
Rigosertib sodium (ON 01910.Na) is a potent, non-ATP-competitive PLK1 inhibitor (IC50=9-10nM), selectively induces mitotic G2/M arrest and apoptosis in cancer cells; also exhibits inhibitory activity against PDGFR, Abl, and Flt-1, at higher concentrations, inhibits CDK1, Plk2, Src, and Fyn; demonstrates in vitro cytotoxicity against DU145 and K562 cells with IC50 of 100 and 15nM; potently inhibits tumor growth in a variety of xenograft nude mouse models, does not exhibit hematotoxicity, liver damage, or neurotoxicity shows strong synergy with several chemotherapeutic agents. Blood Cancer Phase 3 Clinical
Product Categories/Family for Rigosertib sodium, inhibitor
References
1. Reddy MV, et al. J Med Chem. 2011 Sep 22; 54 (18):6254-76.
2. Gumireddy K, et al. Cancer Cell. 2005 Mar; 7 (3):275-86.
3. Oussenko IA, et al. Cancer Res. 2011 Jul 15; 71 (14):4968-76.
4. Chun AW, et al. Cancer Chemother Pharmacol. 2009 Dec; 65 (1):177-86.
2. Gumireddy K, et al. Cancer Cell. 2005 Mar; 7 (3):275-86.
3. Oussenko IA, et al. Cancer Res. 2011 Jul 15; 71 (14):4968-76.
4. Chun AW, et al. Cancer Chemother Pharmacol. 2009 Dec; 65 (1):177-86.
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Product Notes
The Rigosertib sodium (Catalog #AAA3605192) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Rigosertib sodium, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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