DPP10 / DPRP3 recombinant protein

Recombinant Human DPP10 / DPRP3 Protein (His tag)

Cat. Num. AAA2545672

• Gene Names: DPP10; DPL2; DPPY; DPRP3; DPRP-3
• Purity: > 97 % as determined by SDS-PAGE
• Synonyms: DPP10 / DPRP3; Recombinant Human DPP10 / DPRP3 Protein (His tag); DPL2; DPPY; DPRP3; DPP10 / DPRP3 recombinant protein

• Host: Human Cells
• Purity/Purification: > 97 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 789

• Application Notes: The recombinant human DPP10 consists of 760 amino acids and has a calculated molecular mass of 87.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhDPP10 is approximately 90-110 kDa due to glycosylation.
• Predicted N Terminal: His
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for DPP10 / DPRP3 recombinant protein

Background: Inactive dipeptidyl peptidase 10, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP10, is a single-pass type I I membrane protein which belongs to the peptidase S9B family. DPPIV subfamily. It may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. DPP10 / DPRP3 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Genetic variations in DPP10 are associated with susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype , largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.

Description: A DNA sequence encoding the human DPP10 isoform 1 (Q8N608-1) extracellular domain (Leu 56-Glu 796) was expressed, with a polyhistidine tag at the N-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 85787627
• NCBI GeneID: 57628
• NCBI Accession #: NP_001004360.2
• NCBI GenBank Nucleotide #: NM_001004360.3
• UniProt Accession #: Q8N608; Q0GLB8; Q53QT3; Q53S86; Q53SL8; Q53SS4; Q6TTV4; Q86YR9; Q9P236; A8K1Q2; J3KPP2; J3KQ46
• Molecular Weight: 85,480 Da
• NCBI Official Full Name: inactive dipeptidyl peptidase 10 isoform short
• NCBI Official Synonym Full Names: dipeptidyl peptidase like 10
• NCBI Official Symbol: DPP10
• NCBI Official Synonym Symbols: DPL2; DPPY; DPRP3; DPRP-3
• NCBI Protein Information: inactive dipeptidyl peptidase 10
• UniProt Protein Name: Inactive dipeptidyl peptidase 10
• UniProt Gene Name: DPP10
• UniProt Synonym Gene Names: DPRP3; KIAA1492; DPRP-3; DPP X; DPL2

NCBI Description

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).