Structure
INH154, Inhibitor
INH154
Purity
>98% (HPLC)
Synonyms
INH154; INH 154; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 62.5mg/mL (159.23mM)
H2O: <0.1mg/mL
H2O: <0.1mg/mL
Target
Hec1/Nek2
Receptor
Hec1/Nek2
Chemical Name
N-(4-(2, 6-dimethyl-4-(piperidin-1-yl)phenyl)thiazol-2-yl)isonicotinamide
SMILES
CC1=CC(=CC(=C1C2=CSC(=N2)NC(=O)C3=CC=NC=C3)C)N4CCCCC4
Molecular Formula
C22H24N4OS
CAS Number
1587705-63-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for INH154, inhibitor
INH154is a novel small molecules disrupting Hec1/Nek2 interaction, inhibits HeLa and MDA-MB-468 cancer cells growth with IC50 of 0.20 and 0.12uM, respectively; suppresses the growth of leukemia, osteosarcoma, and glioblastoma cells, but has no significant growth inhibitory effects on non-tumorigenic fibroblast, HS27 and mammary epithelial cells; triggers Nek2 degradation and eventually cell death, suppresses tumor growth in mice without obvious toxicity.
Product Categories/Family for INH154, inhibitor
References
1. Hu CM, et al. Oncogene. 2015 Mar 5; 34 (10):1220-30.
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Product Notes
The INH154 (Catalog #AAA3602265) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "INH154, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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