Rabbit anti-Human, Mouse KCNK3 Polyclonal Antibody | anti-KCNK3 antibody

KCNK3 Polyclonal Antibody

Cat. Num. AAA3010640

• Gene Names: KCNK3; OAT1; PPH4; TASK; TASK1; TBAK1; K2p3.1; TASK-1
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: KCNK3; Polyclonal Antibody; KCNK3 Polyclonal Antibody; K2p3.1; OAT1; PPH4; TASK; TASK-1; TBAK1; anti-KCNK3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: KCNK3 polyclonal antibody detects endogenous levels of KCNK3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 394

• Applicable Applications for anti-KCNK3 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant protein of human KCNK3
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using KCNK3 antibody.)

Related Product Information for anti-KCNK3 antibody

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 4504849
• NCBI GeneID: 3777
• NCBI Accession #: NP_002237.1
• NCBI GenBank Nucleotide #: NP_002237.1
• UniProt Accession #: O14649
• Molecular Weight: 38kDa
• NCBI Official Full Name: potassium channel subfamily K member 3
• NCBI Official Synonym Full Names: potassium two pore domain channel subfamily K member 3
• NCBI Official Symbol: KCNK3
• NCBI Official Synonym Symbols: OAT1; PPH4; TASK; TASK1; TBAK1; K2p3.1; TASK-1
• NCBI Protein Information: potassium channel subfamily K member 3
• UniProt Protein Name: Potassium channel subfamily K member 3
• Protein Family: Potassium channel subfamily
• UniProt Gene Name: KCNK3
• UniProt Synonym Gene Names: TASK; TASK1; Two pore K(+) channel KT3.1

NCBI Description

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]

Uniprot Description

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.