Impurity C of Calcitriol, Inhibitor

Impurity C of Calcitriol

Cat. Num. AAA5753323

• Purity: 98.00%
• Synonyms: Impurity C of Calcitriol; inhibitor

• Purity/Purification: 98.00%
• Form/Format: Solid. Powder

• Solubility: <1mg/ml refers to the product slightly soluble or insoluble
• Formula: C35H49N3O5
• SMILES: O[C@@H](C[C@@H]1O)CC([C@@H]2C=C3[C@@](CC[C@]4([H])[C@@H](CCCC(C)(O)C)C)([H])[C@]4(C)CC[C@@]3([H])N(C(N5C6=CC=CC=C6)=O)N2C5=O)=C1C
• CAS Number: 86307-44-0
• Target & IC50: Others
• In Vitro: Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol exhibits antitumor activity; Calcitriol inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin, and brain carcinomas and myeloid leukemia cells.
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent

Structure

Related Product Information for Impurity C of Calcitriol, inhibitor

Impurity C of Calcitriol is an impurity of Calcitriol. Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

References

Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J. Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004)
Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J. Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004)
Calcitriol in cancer treatment, from the lab to the clinic. Mol.Cancer Ther. 3 373.
Calcitriol in cancer treatment, from the lab to the clinic. Mol.Cancer Ther. 3 373.
Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment, and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23.
Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment, and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23.
Alkharfy KM, Al-DaghrinM, Yakout SM, Ahmed M. Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model. Basic Clin Pharmacol Toxicol. 2012 Aug 21.
Alkharfy KM, Al-DaghrinM, Yakout SM, Ahmed M. Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model. Basic Clin Pharmacol Toxicol. 2012 Aug 21.